In our setup (45 min ischemic time and 24 h reperfusion), the downregulation of apoptotic genes, myocardial proinflammatory cytokine tumor necrosis factor-α, hypertrophic marker alpha actin-1, and profibrogenic transforming growth factor-β may at least be due to the activation of the prosurvival PI3K/Akt pathway and the upregulation of antioxidants during the acute phase of diabetes. This evidence concerns the gene PIK3CG and diabetes mellitus.