AKT1 and diabetes mellitus: To that end, we evaluated in vivo the left-ventricular mechanical function with a Millar pressure-volume conductance catheter system, assessed biochemical and histopathological changes, and identified changes in myocardial gene expression relevant to diabetes, apoptosis, oxidative stress, PI3K/Akt signalling, inflammation, cardiac fibrosis, and hypertrophy using an RT2 Profiler PCR Arrays system.