Atorvastatin was also shown to influence the cellular activities of components of the PI3/AKT signaling molecules such as AKT, P2X7, pERK, RhoA, cyclin D1, and β-catenin to inhibit proliferation and induce apoptosis in pancreatic cancer cells [36]. The gene discussed is EIF2AK3; the disease is familial pancreatic carcinoma.