Neonatal AMKL is strongly associated with t(1;22)(p13;q13), a translocation found in approximately 70% of infant AMKL [8], forming the fusion gene RBM15-MKL1, and neonatal AMKL with t(1;22)(p13;q13) was seen in eight out of 13 non-DS neonatal AMKL patients reviewed by Isaacs Jr. This evidence concerns the gene RBM15 and acute megakaryoblastic leukemia.