NR4A1 and neoplasm: These factors include the age, performance status and comorbidity of the patients, the number of involved axillary lymph nodes, the extent of tumour involvement and presence or absence of major extra-nodal extension of disease, size and grade of the primary tumour, evidence of lymphovascular invasion, hormone receptor and Her 2 receptor status, the adequacy of the total mastectomy and surgical margin status, the adequacy of axillary dissection (at least 10 axillary lymph nodes examined), and if systemic chemotherapy or endocrine therapy is employed.