Firstly, we compared the magnitude of the induction of ZNF395 by hypoxia in several tumor cell lines, which were RTS3b cells, an immortalized skin cancer cell line, the cervical cancer cell line C33A, the astrocytoma cell line U87-MG, the human epithelial kidney cell line HEK293, and the monocyte cell line U937. Here, ZNF395 is linked to skin cancer.