Increased expression of ZNF395 could be associated with a poor prognosis in patients with osteosarcomas, Ewing sarcomas [11, 12], and neuroblastomas [13] and may also play a role in the pathogenesis of clear cell renal cell carcinoma (ccRCC) [14–16]. This evidence concerns the gene ZNF395 and nonpapillary renal cell carcinoma.