In this study, we want to investigate the time-dependent protective effects of a single dose of standard Immunoglobulin G (IgG) and immunoglobulin’s enriched with IgA and IgM (IgGAM) intravenous (IV) administration on long-term behavioral alterations including depression and anxiety-like behavior in CLP-induced sepsis model in rats. The gene discussed is CD40LG; the disease is Sepsis.