The authors also demonstrated that HDAC inhibitors, including suberoylanilide hydroxamic acid and vorinostat, ameliorate the phenotype of PH rat models, indicating that increased HDAC activity leads to the pathological condition of PH.7 Another investigation by Wang et al.36 showed that miR-124 has an important role in maintaining homeostasis in fibroblasts and is involved in the pathogenesis of PAH. The gene discussed is HDAC9; the disease is pulmonary arterial hypertension.