miR-320a could regulate the expression of BCR/ABL by directly inhibiting BCR/ABL transcript or other indirect circuits, so we next ascertained whether the reduction of BCR/ABL expression could explain the inhibition of CML cell migration, invasion and proliferation observed after the forced expression of miR-320a. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.