Interestingly, blocking the PI3K/AKT/NF-κB pathway cancelled the effect of miR-320a, which might provide a more comprehensive picture of the molecular network that miR-320a promoted EMT through activating PI3K/AKT/NF-κB pathway in metastasis of CML. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.