Several other molecular alterations, such as echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion [4], Notch signaling activation [5, 6], and dysregulation of the nucleo-cytoplasmic transport of proteins [7], also participate in NSCLC progression. The gene discussed is ALK; the disease is non-small cell lung carcinoma.