AICDA and neoplasm: Nonetheless the activation status of components of the immune system have been associated with genotoxicity to tumor cells due to local production of reactive oxygen and nitrogen species [80] or the activation of mutation inducing machineries such as Recombination Activating Gene (RAG), Activation-induced Cytidine Deaminase (AID) [81] or Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like (APOBEC) proteins [82].