Tumor cells not only recruit leukocytes to the tumor mass through chemokines (such as CSF-1) but are also stimulated by growth factors produced by the leukocytes (such as EGF produced by macrophages [74] and also modulate the function of these infiltrating tumor cells through the production of several immune modulators such as indoleamine 2,3-dioxygenase (IDO), TGF-β, Interleukin (IL)-10, arginase [75] or even lactate, as a result of the Warburg effect on tumor cell metabolism [76]. This evidence concerns the gene TGFB1 and neoplasm.