Following these observations, the eNOS modulatory role of statins and virgin olive oil may have an influence on functional regulation of the cardiovascular system and may offer new perspectives for the better use of statins and phenol-rich olive oil in ameliorating cardiovascular disorders, especially in patients with downregulated eNOS function, such as carriers of the TT allele of the G894T polymorphism. This evidence concerns the gene NOS3 and cardiovascular disorder.