BRCA1 and hereditary cancer: As previously stated, Igf1 was robustly up-regulated in hSOD1G93A microglia; a complex interplay between Brca1 and IGF signalling pathways had been reported in familial cancer, in particular through the convergence of Brca1-mediated tumour protective pathways and IGF1 receptors-mediated cell survival [25, 26].