McCarthy et al.23, 24 have demonstrated that antagonism of PPARγ in rats during pregnancy can induce features of preeclampsia characterized by maternal hypertension, proteinuria and endothelial dysfunction, while the PPARγ agonist, rosiglitazone, can ameliorate the features of preeclampsia in the animal model of reduced uterine perfusion pressure. The gene discussed is PPARG; the disease is endothelial dysfunction.