Furthermore, our data show that TGF-β increased GATA-3 ChIP enrichment of the IL-13 gene by 336 ± 70 % (n = 3; p < 0.01) in PBLs from patients with SSc (Fig. 5e, left panel), whereas TGF-β decreased GATA-3 ChIP enrichment of the IL-13 gene by 70 ± 6 % (n = 3; p < 0.01) in PBLs from healthy donors (Fig. 5e, right panel). The gene discussed is GATA3; the disease is systemic sclerosis.