db/db and HF diet-fed mice were treated with Etomoxir, an inhibitor of carnitine palmi-toyltransferase 1 (CPT1) which was a rate-limiting enzyme for the conversion of long chain acyl-CoA to long chain acylcarnitine, mitoquinone (MitoQ), a mitochondria-targeted antioxidant, and PFT-α, a P53 inhibitor. Here, TP53 is linked to hydrops fetalis.