Comparing the serum levels in CHC and HCC patients we can underline that the concentrations of β-NGF, CXCL9, CXCL12, IL-16, IL-18, IL-2R, Leptin, sIL-6Ra were higher in HCC patients and indicated as possible index of the chronic inflammation leading in CHC patients to the HCC development. Here, LEP is linked to cryohydrocytosis.