IL18 and cryohydrocytosis: In fact, we have confirmed the increased amount of IL-2R, IL-18, HGF, glucagon, and leptin that were found in T2D patients [9] as well as of β-NGF, CXCL1, CXCL9, CXCL12, HGF, IL-2R, s-IL-6Ra, IL-18, IFN-α, IL-16, PECAM-1 and Prolactin found in patients with CHC as well as with HCC and CHC-related cirrhosis [8–9].