In fact, it is known that in CHC patients ADIPOQ was found related to the severity of the fibrosis and suggested as HCC marker when the carcinogenesis is concomitantly supported by CHC infection [20] while β-NGF and IL-16 are involved in cancer growth and metastasis and also detected in diseased liver tissues [9, 21]. Here, IL16 is linked to hepatocellular carcinoma.