Greater amounts of HGF, IL-2R, s-IL-6Ra, IL-18, leptin, sVEGFR-1 and sVEGFR-2 were secreted by T2D, CHC and HCC patients in comparison with the healthy controls, whereas those of glucagon only by T2D and HCC patients, those of β-NGF, CXCL1, CXCL9, CXCL12, IL-16, and PECAM-1 by CHC and HCC patients, and those of IFN-α and Prolactin only in HCC patients. The gene discussed is LEP; the disease is cryohydrocytosis.