Similarly, CXCL1 and CXCL9 have chemotactic activities and roles in angiogenesis, inflammation and tumor genesis [9], CXCL12 is related to the HCC metastatic network by recruiting endothelial cell tumor progenitors [22], and PECAM-1 reflects the liver disease progression [23]. This evidence concerns the gene PECAM1 and hepatocellular carcinoma.