Our present studies have shown that treatment with obestatin expedites spontaneous normalization of pancreatic structure in the course of ischemia/reperfusion-induced AP leading to earlier reduction and/or elimination of pancreatic edema, leukocyte infiltrations of the pancreatic tissue, vacuolization of acinar cells, pancreatic necrosis and number of hemorrhagic foci. Here, GHRL is linked to ischemia.