Although the exact mechanisms through which obestatin can protect and restore tissue blood flow in acutely inflamed pancreas remains unknown it has recently been shown that obestatin along with other preproghrelin gene-derived peptides demonstrates antiapoptotic actions in human pancreatic islet microendothelial cells exposed to chronic hyperglycemia, and the effects and signaling mechanisms induced by the peptides are comparable and also similar to those of the GLP-1R agonist exendin-4 [48]. The gene discussed is GHRL; the disease is Hyperglycemia.