ESR1 and neoplasm: The results obtained with the recessive model remained significant in multivariate Cox regression analysis after adjusting for lymph node status, tumor size, chemotherapy, endocrine therapy, and ER, PR, and HER2 statuses (Table 3) and indicated that the patients with the AA genotype had a relatively higher risk of recurrence (HR = 3.53, 95%CI: 1.98–6.31, P<0.01) compared with those carrying the G allele.