TNFRSF1A and glioblastoma: Our findings in this study reveal how GBM derived gangliosides induce T cell apoptosis (Fig 1) by directly interacting with the TNFRI, thereby recruiting individual components of the death inducing signaling complex (DISC), namely Fas associated death domain (FADD) and TNF receptor associated death domain (TRADD), which in turn activates initiator caspase-8, thereby, activating the receptor dependent pathway of caspase activation.