Obviously, the anti-migratory and EMT inhibitory effects of Nrf2, as reported by contrast in hepatoma cells and myofibroblasts [40,41], rely on the blockade of Smad-dependent signalling, but under conditions of E-cadherin suppression, as in Colo357 and HPDE cells, Nrf2 may favour a migratory phenotype. This evidence concerns the gene CDH1 and hepatocellular carcinoma.