Since RA is an inflammatory disease, key markers and molecules whose levels are increased and involved in RA pathogenesis are, among others, TLR3 and of IL-1β in CD34+ cells, CRP, fibrinogen [156], ROS, MnSOD mRNA, NOX2 mRNA [157], PTX3, which is related to other cardiovascular diseases [158], or anti-IgG4 hinge antibodies that may represent one mechanism of ACPA-mediated inflammation [159]. This evidence concerns the gene PRTN3 and rheumatoid arthritis.