OA has been recently described to be pro-apoptotic in oestrogen receptor-negative/progesterone receptor-negative/HER2-negative (ER−/PR−/Her2−) breast cancer cells [34], and patients with an ER− genotype are considered to have more aggressive, highly invasive breast cancer than patients with an ER+ genotype [35]. This evidence concerns the gene ERBB2 and breast carcinoma.