According to the literature and our previous studies, although still not completely clear, PERK signaling pathway is potentially highly related with the types of human diseases including Alzheimer's disease,98 Parkinson's disease,99 Huntington's disease,100 encephalomyelitis,101 vascular calcification,102 arrhythmias,64 diabetic cardiomyopathy91 and so on. This evidence concerns the gene EIF2AK3 and early-onset autosomal dominant Alzheimer disease.