With potential effects against neurodegenerative diseases, BBR has also exhibited several known effects such as inhibition of monoamine oxidase B (MAO-B), acetylcholinesterase (AChE), up-regulation of nuclear factor erythroid 2 (Nrf2), (glycagon-like protein 1) GLP-1, as well as phosphorylation of Protein kinase B (AKT) and CREB [33–37]. Here, CREB1 is linked to neurodegenerative disease.