If we also consider the poorly understood connection between IgAD levels and autoimmunity, asthma and allergy [6], genetic risk factors of immune-mediated diseases (predominantly inflammatory diseases in our cohort) may theoretically affect the low IgA dogs in our sample set and introduce a bias leading to the association to genomic regions involved in the various immune diseases and not primarily to low IgA levels. The gene discussed is CD79A; the disease is Autoimmunity.