CCND1 and urinary bladder cancer: For instance, Wu and coworkers [58] have recently reported that, in bladder cancer cells, the ERβ ligand resveratrol inhibits cell growth through decreased phosphorylation, nuclear translocation and transcription of STAT3, resulting in the downregulation of the expression of STAT3 downstream genes (cyclin D1, survivin, c-Myc and VEGF).