NRAS and melanoma: Actually, NRAS and BRAF mutations are very frequently found in melanoma tumors; in particular, BLM cells are NRAS-mutant (a mutation present in about 30% of patients), while both A375 and WM1552 cells harbor the BRAF V600E mutation (the predominant BRAF mutation, occurring in about 50% of cases) [31,69,70].