Moreover, Nakamura and coworkers demonstrated that, in prostate cancer cells, activation of ERβ induces cyclin D1 expression through increased expression of FOS and JUN; however, according to the data reported, the authors conclude that the interaction of ERβ with the two transcription factors is not direct and likely involves early responsive genes which still need to be identified [59]. The gene discussed is ESR2; the disease is prostate cancer.