It is noteworthy that ACPA (the most specific biological markers with predictive and prognostic value in RA patients) are elevated in patients’ sera five to 10 years prior to diagnosis with RA [4, 11, 12, 14], suggesting that factors initiating autoimmunity in RA may act before appearance of symptoms and signs characteristic of clinical disease. This evidence concerns the gene PRTN3 and rheumatoid arthritis.