In the same way, the EIRA Swedish population-based study of 1497 incident RA patients compared with 2536 age and sex matched controls investigated the impact of an interquartile range increase (2 μg/m3 for PM10, 8 μg/m3 for SO2, and 9 μg/m3 for NO2) in each pollutant from traffic and home heating sources in the 5th, 10th, and 20th years prior to symptom onset (considering increment of ACPA titers five to 10 years before occurrence of clinical signs and symptoms of RA) and average exposure on the risk of all RA and the risk of RA serologic features. The gene discussed is PRTN3; the disease is rheumatoid arthritis.