Compared with non-users, pre-stroke statin users were more likely to be older and women, to have a pre-stroke disability of mRS 1, a history of hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation, coronary artery disease, and prior stroke, and to have already been on antiplatelet agents, angiotensin-receptor blockers (ARBs) or angiotensin converting enzyme inhibitors (ACEIs), beta-blockers, diuretics, or calcium channel blockers (CCBs). The gene discussed is ACE; the disease is Hypertension.