NOS3 and Stroke: Animal experiments have shown that pretreatment with statin have neuroprotective actions of enhancing angiogenesis, reduction of clot formation or facilitation of clot lysis, and upregulation of endothelial nitric oxide synthase [4–6, 9], and statin treatment after stroke had neurorestorative actions of promoting neurogenesis, synaptogenesis, and angiogenesis [8].