LGALS1 and experimental autoimmune encephalomyelitis: Thus, in contrast to the higher pathology observed in the context of Gal-1 deficiency in other experimental autoimmune models including experimental autoimmune encephalomyelitis (EAE)30 and collagen-induced arthritis (CIA)31, EAO pathology was found to be less severe in Lgals1−/− compared to WT mice, suggesting context-dependent Gal-1-mediated regulation of autoimmune pathology.