The RQ values for OX1R, OX2R and GPR103 in control samples were: 3.2, 1.5, and 1.0, whereas the RQ values for OX1R, OX2R and GPR103 in EOFAD were: 0.08, 0.38 and 0.46 respectively. Here, HCRTR1 is linked to early-onset autosomal dominant Alzheimer disease.