We did not observe a difference in the genotypic frequencies of rs11245007 between patients and controls (P = 0.907), and the results of a case-only analysis indicated that the rs11245007 genotypes were not significantly associated with mean age at diagnosis, lymph node metastasis, and expression status of estrogen receptor (ER) or progesterone receptor (PR) (Additional file 3). The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.