Although rs11245007 T allele (CT + TT) in FATS conferred a reduced risk of breast cancer in individuals with a family history of cancer in Tianjin Discovery cohort, such effect was not replicated in the Replication set of Guangzhou cohort, possibly due to the relatively smaller number of the Replication cohort, particularly for the stratification analysis. This evidence concerns the gene C10orf90 and breast cancer.