According to the p53 data base (http://www-p53.iarc.fr/) of the International Agency for Research on Cancer (IARC), most TP53 mutations in ovarian cancer are, like those in other cancers, missense mutations (>87.56%), which mainly cluster in the DNA binding domain with hotspots at codons 175, 248, and 273. This evidence concerns the gene TP53 and ovarian cancer.