The clotting process is exacerbated by direct interaction between cancer cells and the endothelial cells, by activating blood cells such as monocyte, macrophage, and platelet, and/or by secreting tissue factor, cancer procoagulants, and cytokines from cancer cells.10,11 Interestingly, these coagulation products are also associated with the growth, progression, metastasis, and angiogenesis of cancer.11,12 Therefore, thromboembolism is not only a direct cause of death in cancer patients but also closely related to the death from cancer progression. This evidence concerns the gene F3 and cancer.