In contrast to CRP, reports in the literature have shown that PCT is an early and specific marker of neonatal sepsis, confirming the importance of the latter in excluding infection shortly after birth.10 However, falsely increased PCT concentrations have been reported for critically ill newborns presenting with “apparently” noninfectious conditions.11–16 Although these studies argued for the lack of PCT specificity for the diagnosis of sepsis in neonates, their conclusions should be interpreted with caution. This evidence concerns the gene CRP and Sepsis.