UCHL1 and type 2 diabetes mellitus: While UCHL1-eGFP mice on RD were able to return to baseline blood glucose levels 2 hrs after glucose administration, mice on HFD had significantly higher blood glucose levels, a sign of type II diabetes (Fig 5B; blood glucose levels 2h after administration: 104 ± 0.85 mg/dl in RD, n = 6 mice; 250 ± 3.28 mg/dl in HFD, n = 5 mice; P = 0.0009).