Many important genes as revealed in Table 3 like kirsten rat sarcoma viral oncogene homolog (kras), v-raf murine sarcoma 3611 viral oncogene homolog (araf), phosphoinositide-3-kinase, regulatory subunit 5 (pik3r5), ral guanine nucleotide dissociation stimulator (ralgds) and v-akt murine thymoma viral oncogene homolog 3 (akt3) were observed to contribute maximum complexity in the CRC pathway. This evidence concerns the gene AKT3 and colorectal carcinoma.