Studies illustrate that CRC is mainly associated with chromosome instability (CIN) [16] and microsatellite instability (MSI) pathways [17, 18].Genetic aberrations in genes involved in CIN pathway leads to the activation of oncogenes like kras and inactivate certain tumor suppressor genes such as smad4, p53, smad2, bax and apc [19]. This evidence concerns the gene SMAD4 and cervical squamous intraepithelial neoplasia.