But we found 97% similarity among the two protein sequences (araf and braf) and the two isoforms share several domains such as Raf_RBD, Pkinase, SPS1, TyrKc and biological properties including binding sites; so intending araf as one of the key genes in CRC for its association in disease may prove vital for understanding cancer genetics. This evidence concerns the gene ARAF and colorectal carcinoma.