TNFRSF11B and chronic kidney disease: Similarly when eGFR was dichotomized into above or below stage 3 CKD (eGFR < 60 ml/min/1.73m2) there was a significant interaction with log transformed OPG and stage of CKD for all-cause mortality (P = 0.043) and CVD mortality (P = 0.016) or when dichotomizing by median OPG levels with eGFR (ml/min/1.73m2) the interaction term remained significant for all-cause (P = 0.021) and CVD mortality (P = 0.047).