Compared to participants with below-median OPG levels and eGFR ≥60mL/min/1.73m2, only participants with above-median OPG levels and eGFR <60mL/min/1.73m2 had significantly higher risk of 15-year CVD mortality before (HR 2.33, 95%CI 1.62–3.33, P < 0.001) and after adjustment for age, BMI, treatment, smoking history and prevalent renal disease and diabetes (Fig 2). The gene discussed is TNFRSF11B; the disease is diabetes mellitus.