Taking into account the relationship of DPPIV/CD26 with mechanisms such as cell migration, especially due to its hydrolytic activity that leads to degradation and inhibition of regulatory biopeptides, we evaluated the migration capacity in the SiHa and HeLa cervical cancer cell lines, which had higher and lower enzymatic activity and expression of DPPIV/CD26, respectively. This evidence concerns the gene DPP4 and cervical carcinoma.