In addition, based on the fact that cytokines could have large influence on the HPA axis [33], evidence on the increase of cytokines such as interleukin 1 (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) among the patients with depression and anxiety may further support this theory [34–39]. The gene discussed is IL6; the disease is depressive disorder.