In BD patients, the levels of TNF-α, IL-6 and IL-17 were higher in supernatants of anti-CD3 and CD28-stimulated PBMCs from cases with the GG genotype (P = 0.037, P = 0.034 and P = 0.029, respectively), but the level of IFN-γ was similar amongst these three genotype groups (P = 0.920). Here, TNF is linked to Behcet disease.