NR3C2 and Premature ventricular contraction: In vivo, cardiomyocyte-specific MR overexpression in transgenic mice induces ionic remodeling with a decrease of the outward potassium current (Ito) activity and an increase in L-type Ca channel activity which is associated with ventricular extrasystoles and an increase in sensitivity to the triggering of ventricular arrhythmia [46].