Previous studies have demonstrated colocalization of Notch and c-Src proteins in pancreatic cancer cells, where Src is required for proteolytic activation of Notch (Ma et al., 2012), and of Notch and the T-cell-specific Src family member Lck in T cells (Sade et al., 2004), but a functional relationship between the two genes had not been demonstrated prior to our study. Here, LCK is linked to familial pancreatic carcinoma.