The histological sequence of colorectal carcinogenesis is characterized by several different genetic and epigenetic alterations [7,8], such as inactivating APC mutations in familial adenomatous polyposis (FAP) or the loss of function of the mismatch repair genes in hereditary non-polyposis colorectal cancer (HNPCC) [9,10]. Here, APC is linked to hereditary nonpolyposis colon cancer.