IL10 and infection: Next we compared the IL-10 levels in plasma, and supernatant fluids of cultured spleen cells or liver leukocytes between IL-27R-/- and wild-type mice infected with T. congolense. There was no significant difference in IL-10 production in plasma and supernatant fluids of the cultures between IL-27R-/- and wild-type mice on day 7 after infection (Fig 4B).