Although administration of anti-IFN-γ mAb led to doubled parasitemia in infected IL-27R-/- mice at the peak on day 7 after infection (P<0.05), the infected IL-27R-/- mice treated with anti-IFN-γ mAb efficiently controlled the first wave of parasitemia as infected control mice did (Fig 7A). This evidence concerns the gene IFNG and parasitic infectious disease.