We next assessed the effects of IFN-γ neutralization on weight loss and liver pathology of IL-27R-/- mice infected with T. congolense. Infected IL-27R-/- mice treated with anti IFN-γ mAb had significantly less weight loss than infected IL-27R-/- mice treated with rat-IgG on the late stage of infection (p<0.01, S3A Fig). This evidence concerns the gene IFNG and infection.