AGPAT5 comes from a family of highly conserved enzymes that catalyze the acylation of lysophosphatidic acid (LPA) to phosphatidic acid, the second step in the de novo formation of glycerophospholipids.[20,21] Although the function of most AGPAT isoforms is largely unknown, multiple AGPAT isoforms have been linked to cancer. The gene discussed is AGPAT5; the disease is cancer.