The rs885036 SNP constitutes a C>T nucleotide change in the second intron of GnT-IVa, and is located within a predicted binding site for the highly conserved microRNA-34A (miR-34a).[14,15] MicroRNAs play an important role in post-transcriptional silencing of genes, as their interference with RNA leads to repressed translation or cleavage of RNA.[16] Expression of miR-34a itself is regulated by p53 expression.[17] Cytotoxic stress induced by chemotherapy or irradiation markedly increases miR-34a levels in the presence of p53[18], emphasizing its importance in response to anti-cancer treatment. The gene discussed is TP53; the disease is cancer.