APLN and stroke disorder: Then we for the first time identified: 1) HUK enhanced cerebral blood perfusion and facilitated angiogenesis in rats after stroke; 2) HUK promoted VEGF andapelin/APJ expression in MCAO rats and endothelial cell cultures; 3) The underlying molecular mechanism potentially involved withenhancement expression ofVEGF and apelin/APJ in ERK1/2 dependent way;4) angiogenic effect of HUK was associated with activation of B1 and B2 receptors.