The functional requirement of the PFKFB4 family member for neoplastic metabolism and growth then was reported in 2010 when researchers demonstrated that selective inhibition of PFKFB4 with siRNA suppressed the growth of human lung adenocarcinoma xenografts in athymic mice (U.S. patent publication #8,283,332). Here, PFKFB4 is linked to lung adenocarcinoma.