Considering the significant capacity of the endocrine pancreas to adjust to changes in insulin demand [50], and that the pancreas contains quiescent cells that can proliferate and replace lost cells [51], we believe that the described stimulatory activity of Ld can exert an important beneficial effect during the initial stage of diabetes development when it is potentially possible to expand the still existing β-cell mass through regeneration. Here, INS is linked to diabetes mellitus.