Despite their clinical phenotypes of GCD2 in both mothers and apparent phenotype of GCD1 in both daughters, all the family members examined in this case series were positive for the Arg124His mutation of the TGFB-I gene on chromosome 5, unequivocally confirming the diagnosis of GCD2 in all cases (a.k.a. Avellino Corneal Dystrophy). This evidence concerns the gene TGFBI and corneal dystrophy.