PSEN1 and Alzheimer disease: Regarding hyperphosphorylated tau, immunoprecipitation assays of cortical lysates of triple transgenic mice (3xTg-AD) and APP/PS1 mice showed a significant colocalization between hyperphosphorylated tau and Drp1, and these observations were confirmed by double-labeling immunofluorescence in cortical and hippocampal sections [48].